Both of these matches look like home sides with the clearer chance edge against opponents whose defences are in trouble. Neither is a blowout on paper, but the shape of each game points the same way: the home team should have the ball and the better openings.
Lyon against Angers: Angers have been leaky, giving up around sixteen shots and nearly two expected goals a game, with heavy defeats against Marseille and Brest in their last four league matches. Their own attack is modest and mostly lives on counters and corners. Lyon are missing several players, including the lead striker, and were shut out in their last two games, so this is not a rout. But at home they have been winning 2-1 and 3-2, and the chance count should still lean their way. The most likely flow is Lyon with the larger share of the ball and a one- or two-goal win. That's why I'm siding with Lyon to win by a goal or more.
Frankfurt against Hamburg: Hamburg's back line is badly depleted, with three centre-backs out or doubtful, two midfielders out and two forwards missing, which also blunts their counter threat. Frankfurt score close to three a game and out-create Hamburg in both shots and expected goals, and they won 3-1 against the same opponent only five days ago. Frankfurt's own defence is loose, so Hamburg can still nick a goal, but the central weakness is on the visiting side. That's why I'm siding with Frankfurt at home to take the win.
