Napoli and Roma each have a way to break the other's first defensive action. Roma press the initial pass and send Malen behind the cover; Napoli can find De Bruyne or Højlund and attack the space beside Roma's back three. Dortmund and Frankfurt also bring distinct first-pass routes into the box. Their wide attacks meet defensive lines that have recently needed more than one action to end a move.
Napoli's Politano-to-McTominay connection and Roma's Soulé/Mora-to-Malen route can keep supplying attacks after the first goal. Pellegrini is out after leaving Roma's last match, but Roma still scored twice after his exit; Napoli's Buongiorno and Neres were already missing from their last game. I expect pressure wins and bypassed pressure to produce repeated goalmouth chances. I'm siding with goals in Napoli against Roma.
Dortmund can reach Guirassy through Veerman and their wingbacks, while Frankfurt can find Burkardt first and send Doan or Ebnoutalib on the next pass. Dortmund's travelled core has had the shorter recovery, and Frankfurt's Collins is reported fit after leaving the Köln match. Frankfurt's defensive second contacts and Dortmund's first exit have both been tested lately; Aséko also changed Frankfurt's later supply against Köln. I expect both attacks to keep finding the box beyond the opening exchanges. I'm siding with a high-scoring Dortmund against Frankfurt meeting.