Brest can reach their central receiver without needing long spells of possession. Lyon build more patiently and bring midfield runners into the box. The contest should revolve around deliveries, second balls and the space around the fullbacks.
Ajorque gives Brest a target, Doumbia follows the next ball and Locko supplies from wide. Their chances against Nice and their scoring sequences at Lorient show an attack that has continued to function through the defensive absences. Lyon's concession in Spain came from a cross and a lost runner, which meets Brest's strengths directly.
Tousart and Lloris already started together in Brest's last two matches; Chardonnet and Le Guen are continuing absences. Lyon regain Niakhaté and Nuamah according to the current squad reporting, adding central cover and another attacking receiver. Brest's expected attacking core has the stronger continuity behind my choice.
I expect Lyon to circulate and Brest to contest the first reception and follow-up, with the hosts' longer recovery helping them repeat those efforts. That's why I'm siding with Brest, with the draw protected.