Liverpool's wide service tests Palace's handover between wing-back and outside centre-back. Rennes and Lille face a tighter contest around midfield exits and the space behind advancing wide players. The quality of the next pass should determine how often each attack reaches a useful position.
Barcola and Gakpo have both recently supplied Isak, and Palace have conceded from quick wide deliveries with eleven players. Mateta's domestic suspension and Sarr's absence change Palace's forward outlets, while Larsen is cleared for limited use and Timber has already returned to action. Liverpool's Isak, Wirtz and Gakpo had substitute minutes in Europe, preserving important attacking roles. I expect repeated away pressure and fresh runners around the central striker as the game progresses. That's why I'm siding with Liverpool to win.
Lille's Andre–Mukau screen has recent evidence of interrupting attacks before the final pass. Their Mukau–Diaoune–Mbappe turnover goal also demonstrates an attack without Ueda. Bentaleb is back with the group after illness, and Mbappe's European suspension does not carry into the projected domestic side. Rennes retain Dia and Tamari during Lepaul's absence, with their latest compact approach placing greater emphasis on patient exits. I expect Lille's central connections to keep them competitive through the opening contest and the later changes in box occupation. That's why I'm siding with Lille to finish level or ahead.