Brest can make Lyon defend both Ajorque's first contact and the ball that follows it. Lyon have a central reply through Nuamah and Tolisso after their wide players carry the ball forward. The contest can stay level while those first chances are cleared. Later recoveries and second balls should decide which side finds the extra finish.
Ajorque scored from the next ball at Lorient, and Doumbia can arrive after Brest's wide delivery. Niakhaté is available again for Lyon after missing Sociedad, but Brest's central pair of Tousart and Lloris already played the full Lorient match together. That continuity matters when Brest press and when Tolisso arrives behind Lyon's first forward.
Brest's home chances have persisted through their uneven results, while Lyon's current league away attack has offered fewer finishes and comes through a shorter turnaround. I expect Brest to keep reaching the second ball and force the deciding chance. That's why I'm siding with Brest.